Both teams enter Week 2 looking to clean up opening-day blemishes. The Titans dropped their debut in Denver, where they failed to score a touchdown even though the defense forced four turnovers. Meanwhile, the Rams escaped Houston with a hard-fought 14–9 win, leaning on a sturdy defense and timely turnovers despite battling injuries along their offensive line. With two great defensive fronts battling it out, expect this game to be a grind-it-out, low-scoring affair.
Rams quarterback Matthew Stafford was excellent in Week 1, where he completed 21 of 29 pass attempts for 245 yards and one touchdown with no interceptions. Stafford showcased his quick decision-making, averaging a time to throw of just 2.42 seconds, the second-fastest in the league for the week. The Titans remain optimistic in their future with Cam Ward at the helm. Although Ward completed only 42% of his passes, he delivered some impressive throws, with seven of the incompletions being dropped by his receivers. As Week 2 approaches, all eyes will be on whether the Titans can tighten up their protection, limit mental errors, and give Ward the support he needs to overcome Stafford and the Rams’ defense.
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Game Info
Date: Sunday, September 14, 2025
Start Time: 12:00 p.m. CT
Location: Nashville, Tennessee
Stadium: Nissan Stadium
Network: CBS, Paramount+, NFL+, Sunday Ticket
Betting Odds
Odds courtesy of DraftKings.
Point Spread
LAR -5.5 (-108)
TEN +5.5 (-112)
Moneyline
LAR (-230)
TEN (+190)
Over/Under
41.5
The Rams are favored by 5.5 points over the Titans, with a moneyline of -230 indicating they’re the clear favorite against Tennessee’s +190 underdog odds. The game carries a relatively low over/under of 41.5, suggesting oddsmakers expect a defensive, lower-scoring matchup.
What to Watch For
Offensive Line Injuries & Defensive Opportunities
Both teams enter Week 2 with offensive line concerns that could swing the game. The Rams are dealing with interior injuries to guards Kevin Dotson and Steve Avila, leaving Matthew Stafford vulnerable to Tennessee’s interior rush led by Jeffery Simmons. On the other side, the Titans’ protection issues remain glaring after Cam Ward was sacked six times in Week 1, giving the Rams’ edge rushers featuring Defensive Rookie of the Year Jared Verse a clear chance to wreak havoc. Titans starting right tackle JC Latham has also been declared out for the contest.
Potential for Big Plays: Puka Nacua & Calvin Ridley
Two dynamic receivers headline the explosive-play conversation in this matchup. Puka Nacua’s precision in the slot and yards-after-catch ability can punish Tennessee if their safeties bite on play action or lose track in zone coverage. Calvin Ridley, meanwhile, offers Cam Ward a veteran deep threat who can flip the field in a single snap if the Rams’ corners fail to contain him.
Mental Miscues and Penalties
Discipline will be critical, especially for a young Titans squad that committed 13 penalties for 131 yards in the opener. Drive-killing penalties, along with the six sacks, kept Cam Ward in long down-and-distance situations that a rookie quarterback cannot afford, and unnecessary penalties on defense extended drives for the Broncos in Week 1. If those mistakes persist, the Rams’ efficient offense and opportunistic defense are poised to turn free yards into decisive points.
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