Monday Night Football Best Bets: San Francisco 49ers vs. Arizona Cardinals

Monday Night Football Best Bets: San Francisco 49ers vs. Arizona Cardinals

by November 21, 2022 0 comments

Week 11 comes to an end in Mexico City as the San Francisco 49ers and Arizona Cardinals square off in a pivotal NFC West battle. The Niners are looking to secure a much-needed win to tie the Seattle Seahawks for first place in the division. Meanwhile, the Cardinals need to start winning games quickly before their deficit in the NFC becomes insurmountable. 

Let’s explore our top plays for this evening’s matchup.

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Odds via DraftKings Sportsbook.

Best Bet No. 1: James Conner Anytime Touchdown (+110)

The Cardinals showed off a clear commitment to the running game last week against the Rams. Conner played a whopping 96 percent of snaps, rushing 21 times for 69 yards and two touchdowns. He also caught three passes for 17 yards through the air. In fact, the 27-year-old played so well that Arizona released its backup running back, Eno Benjamin, after the game. In Week 11, we can expect a similar style of offense that allows for passes to move the football down the field followed by a heavy dose of Conner in the red zone. Odds are, he’ll find the end zone at least once. Lock this one in at plus money.

Best Bet No. 2: Jimmy Garoppolo Under 1.5 Passing Touchdowns (+105)

Garoppolo is 10-2 in games where he does not throw a touchdown pass. What does this mean? The 49ers know that they can be successful without requiring their quarterback to do too much. Sure, they trust him to get them down the field, but when it comes time for a big conversion on third down or goal-to-go, the ball belongs in the hands of Christian McCaffrey, Elijah Mitchell, or Deebo Samuel. Plus, the 49ers should take an early lead in this one, meaning Garoppolo’s primary job will be handing the football off to kill the clock. Bank on the 31-year-old hitting the under here.

Best Bet No. 3: Rondale Moore Over 54.5 Receiving Yards (-120)

Moore has quietly put together a phenomenal season, averaging 6.3 catches and 67.2 receiving yards over his last six games — and that includes the Week 7 dud in which he caught just one pass. Moore and DeAndre Hopkins have complemented each other quite nicely, and last week’s injury to Zach Ertz means that the entire wide receiver corps should see more volume on Monday night. We’re going to see a whole lot of that McCoy-to-Moore connection in Mexico City, especially if the Cardinals fall behind early. Take advantage of this juicy bet.


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Andersen is a teenage sportswriter and reporter whose articles have appeared across the Prime Time Sports Talk, Sports Illustrated Kids, FantasyPros, and SB Nation platforms. He has also received credit from RotoWorld, CBS Sports, ESPN, Bleacher Report, USA Today, Yahoo Sports, The Athletic, SB Nation, NBC Sports, NY Post, and dozens of other sports sites for his reporting work.

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